In early 2011 we conducted a literature search to find evidence-based guidelines, systematic reviews, meta analyses and randomised controlled trials from the last few years, to bridge the gap between the evidence-based summaries we published in 2007 and the present day.  Listed below are the references that met our inclusion criteria:

  1. Tohen M, Calabrese J, Vieta E, Bowden C, Gonzalez-Pinto A, Lin D, et al. Effect of comorbid anxiety on treatment response in bipolar depression. Journal of Affective Disorders. 2007 2007 Dec;104(1-3):137-46.
  2. Kauer-Sant’Anna M, Flavio Kapczinski F, Vieta E. Epidemiology and management of anxiety in patients with bipolar disorder.CNS Drugs  23 (11) (pp 953-964), 2009  Date of Publication: 2009.
  3. .McIntyre R, S, Danilewitz M, Liauw S, S, Kemp D, et al. Bipolar disorder and metabolic syndrome: An international perspective.Journal of Affective Disorders  126 (3) (pp 366-387), 2010  Date of Publication: 2010.
  4. Wildes JE, Marcus MD, Fagiolini A. Eating disorders and illness burden in patients with bipolar spectrum disorders.Comprehensive Psychiatry [serial on the Internet]. 2007; (6): Available from:
  5. Wildes JE, Marcus MD, Fagiolini A. Prevalence and correlates of eating disorder co-morbidity in patients with bipolar disorder. Psychiatry Research. 2008 2008 Oct 30;161(1):51-8.
  6. Paris J, Gunderson J, Weinberg I. The interface between borderline personality disorder and bipolar spectrum disorders.Comprehensive Psychiatry  48 (2) (pp 145-154), 2007  Date of Publication: Mar 2007.
  7. Roshanaei-Moghaddam B, Katon W. Premature mortality from general medical illnesses among persons with bipolar disorder: A review. Psychiatric Services  60 (2) (pp 147-156), 2009  Date of Publication: February 2009.
  8. The prevalence and significance of substance use disorders in bipolar type I and II disorder. [References]. Substance Abuse Treatment, Prevention, and Policy Vol2 Oct 2007, ArtID 29.
  9. Fan A, H, Hassell J. Bipolar disorder and comorbid personality psychopathology: A review of the literature. Journal of Clinical Psychiatry  69 (11) (pp 1794-1803), 2008  Date of Publication: November 2008.
  10. Wingo A, P, Ghaemi S, N. A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. Journal of Clinical Psychiatry  68 (11) (pp 1776-1784), 2007  Date of Publication: Nov 2007.
  11. Babic D, Maslov B, Martinac M, Nikolic K, Uzun S, Kozumplik O. Bipolar disorder and metabolic syndrome: comorbidity or side effects of treatment of bipolar disorder. [Review]. Psychiatria Danubina. 2010 2010 Mar;22(1):75-8.
  12. Fazel S, Lichtenstein P, Grann M, Goodwin G, M, Langstrom N. Bipolar disorder and violent crime: New evidence from population-based longitudinal studies and systematic review. Archives of General Psychiatry  67 (9) (pp 931-938), 2010  Date of Publication: September 2010.
  13. Latalova K. Bipolar disorder and aggression. International Journal of Clinical Practice  63 (6) (pp 889-899), 2009  Date of Publication: June 2009
  14. Costa A, M, N. Bipolar disorder: Burden of disease and related costs. Revista de Psiquiatria Clinica  35 (3) (pp 104-110), 2008  Date of Publication: 2008.
  15. Sanches R, F, De Azevedo Marques J, M. Cannabis and mood. Revista Brasileira de Psiquiatria  32 (2) (pp 173-180), 2010  Date of Publication: June 2010.
  16. Le Bec P, -Y, Fatseas M, Denis C, Lavie E, Auriacombe M. Cannabis and psychosis: Search of a causal link through a critical and systematic review. Encephale  35 (4) (pp 377-385), 2009  Date of Publication: September 2009.
  17. Weiss RD, Griffin ML, Jaffee WB, Bender RE, Graff FS, Gallop RJ, et al. A “community-friendly” version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug & Alcohol Dependence. 2009 2009 Oct 1;104(3):212-9.
  18. Quarantini L, C, Netto L, R, Andrade-Nascimento M, Galvao-De Almeida A, et al. Comorbid mood and anxiety disorders in victims of violence with posttraumatic stress disorder. Revista Brasileira de Psiquiatria  31 (SUPPL 2) (pp S66-S76), 2009  Date of Publication: October 2009.
  19. Consoli A, Bouzamondo A, Guile J, -M, Lechat P, Cohen D. Comorbidity with ADHD decreases response to pharmacotherapy in children and adolescents with acute mania: Evidence from a metaanalysis. Canadian Journal of Psychiatry  52 (5) (pp 323-328), 2007  Date of Publication: May 2007.
  20. Nejtek VA, Avila M, Chen LA, Zielinski T, Djokovic M, Podawiltz A, et al. Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. The Journal of clinical psychiatry [serial on the Internet]. 2008; (8): Available from:
  21. Sanchez-Moreno J, Martinez-Aran A, Tabares-Seisdedos R, Torrent C, Vieta E, Ayuso-Mateos J, et al. Functioning and disability in bipolar disorder: An extensive review. Psychotherapy and Psychosomatics  78 (5) (pp 285-297), 2009  Date of Publication: August 2009.
  22. Avila C, C, Cabello M, Cieza A, Vieta E, Ayuso-Mateos J, et al. Functioning and disability in bipolar disorders: A systematic review of literature using the ICF as a reference. Bipolar Disorders  12 (5) (pp 473-482), 2010  Date of Publication: August 2010.
  23. Kilbourne AM, Post EP, Nossek A, Drill L, Cooley S, Bauer MS. Improving medical and psychiatric outcomes among individuals with bipolar disorder: a randomized controlled trial. Psychiatric services (Washington, DC) [serial on the Internet]. 2008; (7): Available from:
  24. Kilbourne AM, Biswas K, Pirraglia PA, Sajatovic M, Williford WO, Bauer MS. Is the collaborative chronic care model effective for patients with bipolar disorder and co-occurring conditions? Journal of Affective Disorders. 2009 2009 Jan;112(1-3):256-61.
  25. Medical comorbidity in bipolar disorder: Reprioritizing unmet needs. [References]. Current Opinion in Psychiatry Vol20(4), Jul 2007, pp 406-416.
  26. Maina G, Albert U, Rosso G, Bogetto F. Olanzapine or lamotrigine addition to lithium in remitted bipolar disorder patients with anxiety disorder comorbidity: a randomized, single-blind, pilot study. Journal of Clinical Psychiatry. 2008 2008 Apr;69(4):609-16.
  27. Newton-Howes G, Tyrer P, North B, Yang M. The prevalence of personality disorder in schizophrenia and psychotic disorders: systematic review of rates and explanatory modelling. [Review] [43 refs]. Psychological Medicine. 2008 2008 Aug;38(8):1075-82.
  28. Pirraglia PA, Biswas K, Kilbourne AM, Bauer MS, Fenn H. A prospective study of the impact of comorbid medical disease on bipolar disorder outcomes. Journal of Affective Disorders [serial on the Internet]. 2009; (3): Available from:
  29. Sheehan DV, McElroy SL, Harnett-Sheehan K, Keck PE, Janavs J, Rogers J, et al. Randomized, placebo-controlled trial of risperidone for acute treatment of bipolar anxiety. Journal of Affective Disorders [serial on the Internet]. 2009; (3): Available from:
  30. Wu JC, Kelsoe JR, Schachat C, Bunney BG, DeModena A, Golshan S, et al. Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biological Psychiatry. 2009 2009 Aug 1;66(3):298-301.
  31. Kilbane E, J, Gokbayrak N, S, Galynker I, Cohen L, et al. A review of panic and suicide in bipolar disorder: Does comorbidity increase risk? Journal of Affective Disorders  115 (1-2) (pp 1-10), 2009  Date of Publication: May 2009.
  32. Salloum IM, Douaihy AB, Kelly TM, Cornelius JR, Kirisci L. Advantage of an integrated individual psychotherapy over treatment-as-ususl for comorbid bipolar and addictive disorders: risults from a randomized pilot study. Proceedings of the 70th Annual Scientific Meeting of the College on Problems of Drug Dependence; 2008 June 14-19; San Juan, Puerto Rico, USA [serial on the Internet]. 2008: Available from: